Page 14 - Confidence Interval News Today

1. In this randomized controlled trial, botulinum toxin was more effective than placebo in treating isolated or essential head tremor at 18 weeks follow-up. 2. Adverse events occurred more frequently in the botulinum toxin group including head and neck pain, posterior cervical weakness, and dysphagia. Evidence Rating Level: 1 (Excellent) Study Rundown: Essential tremor is

A randomized trial examining acupuncture in people with CSU suggests use of acupuncture could improve UAS7 scores in these patients, but investigators noted this failed to reach the threshold for significance.

1. In this randomized controlled trial, treatment of patients with complicated Staphylococcus aureus (S. aureus) bacteremia with ceftobiprole was non-inferior to treatment with daptomycin. 2. Secondary outcomes were consistent between the ceftobiprole and daptomycin treatment groups, including mortality, relapse, and microbiologic eradication. Evidence Rating Level: 1 (Excellent) Study Rundown: S. aureus is a leading cause of

The approval is based on the pivotal TRIDENT-1 trial, in which Augtyro successfully achieved a high objective response rate and durable response1 Augtyro adds to Bristol Myers Squibb’s growing...

Ahmad Masri, MD, MS, discusses new acoramidis data from the ATTRibute-CM trial at AHA 2023.

1. In this randomized controlled trial, percutaneous coronary intervention (PCI) performed under optical coherence tomography (OCT) was associated with fewer major adverse cardiac events (MACEs) as compared to conventional angiography-guided PCI. 2. OCT-guided PCI did not differ significantly from the angiography-guided approach in the risk of complications. Evidence Rating Level: 1 (Excellent) Study Rundown: In

1. In this randomized controlled trial, patients with polymyalgia rheumatica (PMR) flares who received sarilumab with a prednisone taper demonstrated increased sustained remission rates compared to those who received a placebo plus prednisone taper. 2. Sarilumab use led to increased rates of adverse events leading to treatment discontinuation compared to placebo, including neutropenia, arthralgias, and

In an interview at AHA 2023, Deepak Bhatt, MD, MPH, discusses recent advancements in cardiovascular risk management, with a focus on the evolving recognition of inflammation, Lp(a), and obesity as modifiable risk factors.

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1. In this randomized controlled trial, tight versus liberal blood glucose control resulted in similar intensive care unit (ICU) outcomes. 2. There were no differences in 90-day mortality following ICU discharge between tight blood glucose control and liberal blood glucose control strategies. Evidence Rating Level: 1 (Excellent) Study Rundown: Low blood sugar levels are common