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Predicting drug absorption in miniatured human liver

Kyoto University The Kazuo Takayama lab reports that PDMS-based liver-on-chip naturally absorb some drugs, which affects drug toxicity results. Liver-on-a-chip are miniaturized devices that capture the physiological and mechanical properties of the liver. They are commonly used by researchers to study how the liver metabolizes different compounds and drugs. In a new study seen in ACS Biomaterials Science & Engineering, CiRA Junior Associate Professor Kazuo Takayama and colleagues repo...
United States Emi Sano Fumiyoshi Yamashita Ryosuke Negoro Hiroyuki Mizuguchi Kazuo Takayama

Stem cells show gender differences in COVID-19 risk

Kyoto University Graphical abstract The Kazuo Takayama lab shows how iPS cells can be used to study SARS-CoV-2 and COVID-19. With more than 125 million people infected and nearly 3 million dead, the COVID-19 pandemic has disrupted the world in inconceivable ways. Adding to the challenge is that the patient condition varies widely, from the asymptomatic to respiratory failure and death. A new study by CiRA researchers shows how iPS cells can be used to study infection by the severe acu...
Emi Sano Yukiko Muramoto Ayaka Sakamoto Takuya Yamamoto Takeshi Noda Kazuo Takayama

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