Page 24 - Gene Expression News Today

EGR1 Inhibits Pro-Inflammatory Gene Expression in Macrophages January 14, 2021 Researchers at The Wistar Institute say they have discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation, maintenance, and resolution of inflammation. The discovery expands the u...

New genomics resource details the small RNA transcriptomes of four mosquito species Researchers from Boston University School of Medicine (BUSM) provide a new genomics resource that details the small RNA transcriptomes (gene expression) of four bio-medically important mosquito species. This is the first study to provide a platform for biologists to compare the characteristics of these small RNAs between these four mosquitoes as well as the most widely used insects for genetic experiments, the f...

As the COVID-19 pandemic continues to infect people in their hundreds of thousands around the world, a new study describes a panel of novel tests for genomic (g) and subgenomic (sg) mRNAs generated by SARS-CoV-2. Most assays in use at present are either qualitative or semi-quantitative, and cannot evaluate the transcription molecules in detail.

EGR1 protein acts as a master regulator of inflammation in macrophages, study suggests Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. As part of their function to protect the body against pathogens, macrophages play a major role in initiation, maintenance, and resolution of inflammation. The discovery expands the understa...

Caption: Myriam Heiman (left) and Alan Jasanoff have received grants to screen for genes that could help brain cells withstand Parkinson’s disease and to map how gene expression changes in the brain in response to drugs of abuse. Caption: An immunofluorescence image taken in a brain region called the substantia nigra (SN) highlights tyrosine hydroxylase, a protein expressed by dopamine neurons. This type of neuron in the SN is espe...

Hypoxia signaling pathway could lead to COVID-19 treatments Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19). The team conducted a study showing that hypoxic (oxygen-deficient) conditions reduced the expression of host cell receptors for the causative agent – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypoxic conditions reduced expression of angiotensin-converting ...

Study monitors spatial shifts of liver gene expression in relationship to the circadian clock Nothing in biology is static. Biological processes fluctuate over time, and if we are to put together an accurate picture of cells, tissues, organs etc., we have to take into account their temporal patterns. In fact, this effort has given rise to an entire field of study known as "chronobiology". The liver is a prime example. Everything we eat or drink is eventually processed there to separate nutrient...

Study shows how intestinal stem cells constantly renew and give rise to specialized cell types The gut plays a central role in the regulation of the bodys metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide. Targeting endocrine dysfunction at an early stage by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerativ...

Researchers identify biomarkers in sperm for paternal offspring autism susceptibility Biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder. These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. In a study published in the journal Clinical Epigenetics on Jan. 7, rese...

New approach can help identify novel treatments for autoimmune diseases A team of researchers led by the Indiana Biosciences Research Institute Diabetes Centers Scientific Director Decio L. Eizirik, MD, Ph.D., has found that identifying new treatments for autoimmune diseases requires studying together the immune system and target tissues. This study, "Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis," is featured ...