Page 22 - Gene Expression News Today

Researchers in the United States have conducted a study demonstrating that a gene called CXCR6 (C-X-C Motif Chemokine Receptor 6) may play an important role in determining the severity of COVID-19.

When the Covid-19 pandemic struck in early 2020, doctors and researchers rushed to find effective treatments. There was little time to spare.

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defenses: these become, thus, the tumor-associated macrophages (TAMs). An article published in the journal Cancer Research...

Researchers find a way to measure key characteristics of proteins that bind to RNA A team of Case Western Reserve University researchers has found a way to measure key characteristics of proteins that bind to RNA in cells--a discovery that could improve our understanding of how gene function is disturbed in cancer, neurodegenerative disorders or infections. RNA--short for ribonucleic acid--carries genetic instructions within the body. RNA-binding proteins play an important role in the regulatio...

Modified CRISPR/Cas9 complex targets specific histones Finding a needle in a haystack is hard enough. But try finding a specific molecule on the needle. Rice University researchers have achieved something of the sort with a new genome editing tool that targets the supporting players in a cells nucleus that package DNA and aid gene expression. Their work opens the door to new therapies for cancer and other diseases. Rice bioengineer Isaac Hilton, postdoctoral researcher and lead author Jing Li a...

Study identifies major flaws in iBMEC-based models of the blood-brain barrier A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center. The cell, known as an induced Brain Microvascular Endothelial Cell (iBMEC), was first described by other researchers in 2012, and has been used to m...

Dublin, Feb. 08, 2021 (GLOBE NEWSWIRE) -- The "Global Genomic Data Analysis and Interpretation Market: Focus on Products, Genomic Platforms,...

Elevated ACE2 and inflammation levels increase risk for pregnant women infected with SARS-CoV-2 Among the hundred million or so cases of coronavirus disease 2019 (COVID-19) that have occurred since the pandemic began, pregnant women have been a conspicuous risk group. However, the exact nature of the risk they and their fetuses face, and the mechanism by which it operates, is far from clear. A new preprint research paper posted to the medRxiv* server throws some light on this area by revealing...

Scientists study how different genes dance to the circadian rhythm In 2017, the Nobel Prize in Physiology or Medicine went to three scientists who uncovered the molecular mechanisms that control the circadian rhythm, otherwise known as the "wake-sleep" cycle. To carry out their work, the scientists used the common fruit fly Drosophila melanogaster, making this the sixth Nobel to be awarded to research involving it. Fruitful fruit flies Life scientists have been using Drosophila for over a cen...

Novel method for identifying biomarkers may aid in early cancer diagnosis A new University of California, Irvine-led study finds a new method for identifying biomarkers may aid in early cancer diagnosis. The study focused on lung cancer, however the Cell Heterogeneity-Adjusted cLonal Methylation (CHALM) method has been tested on aging and Alzheimers diseases as well and is expected to be effective for studying other diseases. We found the CHALM method may be a valuable tool in helping researche...