Page 21 - Gene Expression News Today

RNA editing events influence gene expression and phenotypic manifestation Combining computational mining of big data with experimental testing in the lab, researchers at Childrens Hospital of Philadelphia (CHOP) have identified RNA editing events that influence gene expression and, in turn, the phenotypic manifestation of that expression. In analyzing so-called A-to-I RNA editing, in which the adenosine of an RNA molecule is chemically modified into an inosine, the researchers describe how a si...

Working under a Health Canada research license, the Aging-US authors developed over 800 new C. sativa cultivars and hypothesized that high-CBD C. sativa extracts may be used to down-regulate ACE2 expression in target COVID-19 tissues. Using artificial 3D human models of oral, airway and intestinal tissues, they identified 13 high-CBD C. sativa extracts that decrease ACE2 protein levels. Some C. sativa extracts down-regulate serine protease TMPRSS2, another critical protein required for SAR...

New research by a team of scientists at University Hospital RWTH Aachen in Germany and Erasmus Medical Centre in The Netherlands characterized changes in CD8+ T cells in response to SARS-CoV-2.

Using decision theory for precise choice of breast cancer treatment The precise choice of treatment for breast cancer depends upon the status of the hormone receptors (for estrogen and progesterone). Their conventional determination by means of immunohistochemistry (IHC) is associated with a certain error rate, which can be reduced by adding genomic data. Even conventional statistics can bring about a notable improvement but now it is possible to use decision theory to optimally combine diagnos...

Quantifying Isolated Nuclei from Mouse Brain Using the CellDrop™ FL Automated Cell Counter Isolating nuclei is an essential step in both single nuclear RNA-sequencing and ATAC-sequencing workflows. It is important to ensure that samples obtained during library preparation are non-clustered and debris-free, but nuclei isolated from tissue samples in areas like the brain are prone to high debris in comparison with samples obtained from cultured cells. It is also important that nuclei are accura...

Deep learning-based splice-AI can help predict the onset of Alzheimers disease Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI. This research outcome was published in PNAS, a world-renowned academic journal. Prediction of Alzheimers Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Appro...

Retroviruses invading the koala germline contribute to high cancer rates Koalas are facing multiple environmental and health issues which threaten their survival. Along with habitat loss - accelerated by last year’s devastating bush fires – domestic dog attacks and road accidents, they suffer from deadly chlamydial infections and extremely high frequency of cancer. An international team of scientists led by the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) now demonstrate th...

D, E) CTSG overexpression reduced the migration and invasion ability of OSCC cell lines. NC stands for negative control, while CTSG-OE represents CTSG overexpression. Significant differences were supposed at * P 0.05; ** Discussion Owing to the high recurrence rate and unsatisfied prognosis, OSCC poses a great challenge to modern healthcare. Recently, studies have demonstrated that the immune system was associated with OSCC initiation and progression. 7 Therefore, it might be helpful to identi...

Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations.

Polycomb complexes found to be essential for proper skin development Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18. This latest discovery could improve development of future stem cell therapies to generate "skin on a dish" to transplant into burn victims and patients with skin-blistering disorders. Polycomb...