Biggest News Aggregation in the World
📰 Inflammatory Response News

Page 3 - Inflammatory Response News Today

Fast, Ad-Free News Updates

Stay updated with breaking news from Inflammatory Response. Real-time updates on events, politics, business and more.

Stay Updated with Latest News

Get breaking news updates delivered to your inbox

Browse All News →

Frontiers | The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T c...
United States Western Australia Le Bon Scandj Rheumatol Rheumatol Oxford M Ulcerans Mycolactone Cytotoxicity

Explore More Categories

World News India News Business Technology Sports Entertainment Health Science