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Diverse Ancestries Yield More Predictive Genetic Risk Scores for Heart Disease

A genome-wide association study (GWAS) on 120 primary studies including 1.65 million participants including nearly 350,000 participants from non-European ancestries, shows including participants of diverse ancestries facilitates the identification of genomic variants that are more strongly associated with cardiovascular diseases. The authors noted, trans-ancestry GWAS will help identify effector genes and allow for accelerated biological insight and identification of potential drug targets.
Ann Arbor United States Cashell Jaquish Cristen Willer Amy Bentley Charles Rotimi

Diverse genome sequences provide a powerful tool for studying risk of heart disease

In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.
Ann Arbor United States Harry Wedel Cashell Jaquish Cristen Willer Charles Rotimi
Source: genome.gov

Diverse genome sequences generate a polygenic risk score to predict heart disease risk

In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.
Ann Arbor United States Cashell Jaquish Cristen Willer Charles Rotimi Emily Henderson

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