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Study provides new insight on how experiences shape our current mood

Study provides new insight on how experiences shape our current mood New insight on how our experiences during a task or interaction shape our current mood has been published today in the open-access eLife journal. The study suggests that early experiences may have a larger effect on our mood than more recent events. These findings hold implications for the timing of events in experimental or clinical settings, and suggest new directions for mood interventions tailored to individual patients. ...
Emily Henderson National Institutes Of Health Postdoctoral Research Fellow Hanna Keren Intramural Research Program National Institute Mental Health

Multiple Sclerosis: Chronic White Matter Inflammation Tied to Serum NfL

Findings further support paramagnetic rim lesions as MS biomarker Paramagnetic rim lesions (PRL), a manifestation of chronic white matter inflammation seen on MRI, were associated with elevated levels of serum neurofilament light chain (NfL), a marker of axonal damage, in people with multiple sclerosis (MS), a cross-sectional study found. MS patients with two or more
Noord Holland Fondazione Italiana Sclerosi Multipla Paul Smyth Marie Sklodowska Curie European Union Horizon Dutch Ms Research Foundation

Memory biomarkers confirm aerobic exercise helps cognitive function in older adults

 E-Mail IMAGE: The enhanced physical activity group underwent 26 weeks of supervised treadmill training. Blood samples for both groups were taken at baseline and after 26 weeks. view more  Credit: Florida Atlantic University Increasing evidence shows that physical activity and exercise training may delay or prevent the onset of Alzheimers disease (AD). In aging humans, aerobic exercise training increases gray and white matter volume, enhances blood flow, and improves memory function. ...
United States Soult Ukpyolsi South Korea Madison School University Of Wisconsin Palm Beach County

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A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases

Mechanisms of many human chronic diseases involve abnormal action of the immune system and/or altered metabolism. The microbiome, an important regulator of metabolic and immune-related phenotypes, has been shown to be associated with or participate in the development of a variety of chronic diseases. Viruses of bacteria (i.e., “phages”) are ubiquitous and mysterious, and several studies have shown that phages exert great control over the behavior—and misbehavior—of their host bacteria. T...
Nathan Fons Gabriel Starrett Linda Frisse National Cancer Institute Genbank National Center National Library Of Medicine
Source: pnas.org

Scientists discover a new genetic form of ALS in children

 E-Mail IMAGE: NIH researchers discovered a new form of ALS that begins in childhood. The study linked the disease to a gene called SPLTC1. As part of the study, NIH senior scientist... view more  Credit: Courtesy of the NIH/NINDS. In a study of 11 medical-mystery patients, an international team of researchers led by scientists at the National Institutes of Health and the Uniformed Services University (USU) discovered a new and unique form of amyotrophic lateral sclerosis (ALS). Unlik...
United States Teresam Dunn Payam Mohassel Claudia Digregorio Thorsten Hornemann Pope Francis

Full-Genome CRISPR Screen Reveals Surprsing Ways Neurons Survive Oxidative Stress

Image credit: Kampmann Lab When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the cell. In a new study appearing May 24 in Nature Neuroscience, UCSF researchers have successfully catalogued this effect in the human neuron by separately toggling each of the 20,000 genes in the human genome. In doing so, they’ve created a technique that can be employed for many different cell types, as well as a database where other resea...
Kun Leng Martin Kampmann Anthony Abarientos Jonathan Weissman Nina Draeger Jason Hong
Source: ucsf.edu

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