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Pathway preferential estrogens may be a safer alternative to hormone replacement therapy, study shows

Postmenopausal women have increased risk of non-alcoholic fatty liver disease due to loss of estrogen from metabolic changes. A high-fat diet further exacerbates the disease, which can progress to cirrhosis and liver failure.
John Katzenellenbogen Zeynep Madak Erdogan Emily Henderson Na University Of Illinois Department Of Food Science Food Science

Leerink Partners Remains a Hold on Radius Health (RDUS)

Markets Leerink Partners analyst Geoff Porges maintained a Hold rating on Radius Health (RDUS – Research Report) on April 22. The company’s shares closed last Friday at $20.90. According to TipRanks.com, Porges is a 3-star analyst with an average return of 5.9% and a 49.5% success rate. Porges covers the Healthcare sector, focusing on stocks such as Alexion Pharmaceuticals, Vertex Pharmaceuticals, and Theravance Biopharma. Radius Health has an analyst consensus of Moderate Buy, with a pric...
Michael Rosenblatt Stavrosc Manolagas Theravance Biopharma John Katzenellenbogen Geoff Porges Johnt Potts
Source: markets.co

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Seeing if Hormone Therapy Will Work for Breast Cancer Patients

Seeing if Hormone Therapy Will Work for Breast Cancer Patients Only around half of the women diagnosed with breast cancer will benefit from hormonal therapy, a cancer treatment that adds, blocks, or removes specific hormones to stall the growth and spread of breast cancer cells. The women who respond to these therapies are hormone receptor-positive, meaning that the breast tumor cells carry functional receptors for estrogen or progesterone or both.  The problem is that until now, there is no s...
Farrokh Dehdashti John Katzenellenbogen University Of Illinois Nature Communications Washington University In St Washington University

Imaging shows who'll benefit from breast cancer hormone therapy

An imaging test that measures the function of estrogen receptors in breast cancer cells can distinguish patients likely or unlikely to benefit from hormone therapy, a new study shows. Hormone therapy is commonly given as a targeted treatment for women whose cancer cells carry receptors for estrogen. But the therapy only works for about half of all patients. Until now, there hasn’t been a good way to reliably predict who will benefit and who will not. In a small phase 2 clinical trial, researc...
United States Farrokh Dehdashti Michael Welch John Katzenellenbogen Cynthia Ma Barrya Siegel

Imaging identifies breast cancer patients unlikely to benefit from hormone therapy

 E-Mail IMAGE: Bright spots indicate that cancer cells have responded to a one-day challenge with estrogen in this positron emission tomography (PET) scan of a woman with breast cancer. In a small... view more  Credit: Farrokh Dehdashti Hormone therapy commonly is given as a targeted treatment for women whose cancer cells carry receptors for estrogen. But the therapy only works for about half of all patients. Until now, there hasnt been a good way to reliably predict who will benefit an...
United States Farrokh Dehdashti Michael Welch John Katzenellenbogen Cynthia Ma Barrya Siegel

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