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Mutant gene-targeted immunotherapy approach developed

Two of the three research studies -- led by Jacqueline Douglass, M.D., Ph.D. candidate at the Johns Hopkins University School of Medicine and Emily Han-Chung Hsiue, M.D., Ph.D., postdoctoral fellow at Johns Hopkins--report on a precision medicine immunotherapy approach that specifically kills cancer cells by targeting mutant protein fragments presented as antigens on the cancer cell surface. Although common across cancer types, p53 mutations have not been successfully targeted with drugs. Genet...
United States Michaelb Murphy Shibin Zhou Emily Han Nickolas Papadopoulos Michael Hwang

Insight about tumor microenvironment could boost cancer immunotherapy

 E-Mail IMAGE: Cancer evades the immune system by "feeding " the T cells that protect the tumor and "starving " the T cells that would attack. view more  Credit: UPMC, created with BioRender.com PITTSBURGH, Feb. 15, 2021 - A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy....
United States Mclane Watson Abigail Overacre Delgoffe Jeffrey Rothstein Brett Morrison Natalie Rittenhouse

Mark Foundation announces 2021 Emerging Leader Awards

 E-Mail The Mark Foundation for Cancer Research (MFCR) has awarded seven grants to promising early-career investigators for projects aimed at addressing unmet needs in cancer research. The Emerging Leader Award program empowers scientists to take on innovative, high-risk/high-reward projects that have significant potential to improve outcomes for cancer patients. The 2021 MFCR Emerging Leaders are pursuing important studies in areas of basic, translational, and clinical cancer research, includ...
United States Michele Cleary Zhao Zhu Ken Hsu Paul Cohen Effie Apostolou

Don't sacrifice cancer care to COVID - New York Daily News

The toll from COVID is immense, with more than 90 million people affected and nearly 2 million dead across the world. Yet these numbers don’t tell the full story. The pandemic’s collateral damage in other diseases, like cancer, is rising and will only make itself fully felt in the next few years.
United Kingdom United States Mark Foundation For Cancer Research American Cancer Society Mark Foundation Cancer Research

Damon Runyon Cancer Research Foundation awards $2.65M to innovative scientists

 E-Mail The Damon Runyon Cancer Research Foundation announced that seven scientists with novel approaches to fighting cancer have been named 2021 recipients of the Damon Runyon-Rachleff Innovation Award. Five initial grants of $400,000 over two years were awarded to early career scientists whose projects have the potential to significantly impact the prevention, diagnosis and treatment of cancer. Each project will have the opportunity for up to two additional years of funding (four years total...
United States Debbie Rachleff Mandard Muzumdar Joshuaa Weinstein Xiaochun Li Luisaf Escobar Hoyos

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'Virtual biopsies' could replace tissue biopsies in future thanks to new technique

Credit: Evis Sala/University of Cambridge A new advanced computing technique using routine medical scans to enable doctors to take fewer, more accurate tumour biopsies, has been developed by cancer researchers at the University of Cambridge. This is an important step towards precision tissue sampling for cancer patients to help select the best treatment. In future the technique could even replace clinical biopsies with virtual biopsies, sparing patients invasive procedures. The research publis...
United Kingdom Fiona Barve Evis Sala Paula Martin Gonzalez Cancer Research United Kingdom Cambridge Institute Department Of Radiology

'Virtual biopsies' could replace tissue biopsies in future thanks to technique developed by Cambridge scientists

Date Time ‘Virtual biopsies’ could replace tissue biopsies in future thanks to technique developed by Cambridge scientists A new advanced computing technique using routine medical scans to enable doctors to take fewer, more accurate tumour biopsies, has been developed by cancer researchers at the University of Cambridge. This is an important step towards precision tissue sampling for cancer patients to help select the best treatment. In future the technique could even replace clinical biops...
United Kingdom Fiona Barve Paula Martin Gonzalez Evis Sala Cancer Research United Kingdom Cambridge Institute Department Of Radiology

$17 Million To Boost Leukemia & Lymphoma Research

$17 Million To Boost Leukemia & Lymphoma Research December 23, 2020 The Leukemia & Lymphoma Society (LLS), Rye Brook, N.Y., has inked deals with cancer institutions, foundations and philanthropists to fund roughly $9 million in new research grants in 2020, with up to $8 million more in funding anticipated for early 2021. The funds will underwrite research in improved treatments and potential cures for those with leukemia, lymphoma, myeloma and a variety of blood cancers. The new funding comes a...
Lee Greenberger Foundation For Childhood Cancer Research Hairy Cell Leukemia Foundation Leukemia Lymphoma Society Md Anderson Cancer Center Moffitt Cancer Center

MFCR awards new grants to support an emerging approach to cancer therapeutics

MFCR awards new grants to support an emerging approach to cancer therapeutics The Mark Foundation for Cancer Research (MFCR) has awarded five new grants in support of an important, emerging approach to cancer therapeutics. The projects are centered around the molecular strategy of induced proximity, which involves controlling the physical distance between proteins to regulate or perturb biological processes in the cancer cell. One of the biggest challenges in developing new cancer therapies is ...
United States H Courtney Hodges Michele Cleary Benjamin Stanton Nate Hathaway Becky Bish

The Mark Foundation awards grants to accelerate new class of cancer drugs based on induced proximity

 E-Mail NEW YORK - The Mark Foundation for Cancer Research (MFCR) has awarded five new grants in support of an important, emerging approach to cancer therapeutics. The projects are centered around the molecular strategy of induced proximity, which involves controlling the physical distance between proteins to regulate or perturb biological processes in the cancer cell. One of the biggest challenges in developing new cancer therapies is that many proteins are not tractable to the traditional a...
United States H Courtney Hodges Michele Cleary Benjamin Stanton Nate Hathaway Becky Bish

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