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Novel CRISPR Tool Activates Instead of Editing Human Immune Cell Genes

A research team used a method called CRISPRa to activate each gene in the genome in different cells, enabling them to test almost 20,000 genes in parallel. This allowed them to quickly learn the rules about which genes provide the most powerful levers to reprogram cell functions in ways that could eventually lead to more powerful immunotherapies.
Ralf Schmidt Zachary Steinhart Alex Marson Innovative Genomics Institute Institute Of Genomic Immunology Marson Lab

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