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ALS: The Optimal Treatment Window May Open Earlier Than Expected

May 4, 2021 The key to optimal treatment of amyotrophic lateral sclerosis (ALS) may be to initiate treatment before symptoms emerge—a difficult, but intriguing, hypothesis that will soon be tested in a clinical trial. That trial, known as ATLAS, will evaluate the best timing to begin treatment with the investigational antisense oligonucleotide tofersen in presymptomatic SOD1 mutation carriers at high risk for ALS. The ATLAS trial will assess levels of the axonal injury marker neurofilament...
United States Trinity College University Of Miami Timothy Miller Paul Smyth Michael Benatar

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