Mol Cell News Today

This article explores how Immunoprecipitation can be used to capture IL-6 from human serum forNext-Generation Protein Sequencing.

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Sleep and neuroendocrine function are disrupted following TBI.

Want to lighten up and slide effortlessly into summer fun? Eating these nine foods is a great way ...

Nuclear genes with mutations remain the primary focus for selecting biological drug targets, but we have yet to see a drug come to market from a...

Reviewing the effect of metabolites on mitochondrial functions in the pathogenesis of skeletal muscle aging. Read more

The successive emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has presented a major challenge in the management of the coronavirus disease (COVID-19) pandemic. There are growing concerns regarding the emerging variants escaping vaccines or therapeutic neutralizing antibodies. In this study, we conducted an epidemiological survey to identify SARS-CoV-2 variants that are sporadically proliferating in vaccine-advanced countries. Subsequently, we created HiBiT-tag...

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T c...

Predicted biological functions were validated using gene set enrichment analysis (GSEA) and ClueGo analysis.

Background Glioma is a lethal primary tumor of central nervous system. Ferroptosis is a newly identified form of necrotic cell death. Triggering ferroptosis has shown potential to eliminate aggressive tumors. GPX7, a member of glutathione peroxidase family (GPXs), has been described to participate in oxidative stress and tumorigenesis. However, the biological functions of GPX7 in glioma are still unknown. Methods Bioinformatics method was used to assess the prognostic role of GPX7 in glioma. CCK...