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Safety and immunogenicity of aerosolised Ad5-nCoV, intramuscular Ad5-nCoV, or inactivated COVID-19 vaccine CoronaVac given as the second booster following three doses of CoronaVac: a multicentre, open-label, phase 4, randomised trial

A heterologous fourth dose (second booster) with either aerosolised Ad5-nCoV or intramuscular Ad5-nCoV was safe and highly immunogenic in healthy adults who had been immunised with three doses of CoronaVac.
Long Li United States Peng Wan Xue Wang Tao Zhu J Clin Microbiol

Why does convalescent plasma therapy for severe COVID-19 show mixed success?

Why does convalescent plasma therapy for severe COVID-19 show mixed success? Treatment modalities against the coronavirus disease 2019 (COVID-19) pandemic are limited in efficacy. This has led many centers to use convalescent plasma from recovered COVID-19 patients in the management of this condition. A surprising new preprint, released on the medRxiv* server, suggests that the beneficial effects of convalescent plasma (CP) in this disease stem not only from the presence of neutralizing antibo...
Liji Thomas Functional Antibodies Image Credit Fcr Binding Igg N Specific Igg S Specific Igg

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