Safety and immunogenicity of aerosolised Ad5-nCoV, intramuscular Ad5-nCoV, or inactivated COVID-19 vaccine CoronaVac given as the second booster following three doses of CoronaVac: a multicentre, open-label, phase 4, randomised trial

A heterologous fourth dose (second booster) with either aerosolised Ad5-nCoV or intramuscular
Ad5-nCoV was safe and highly immunogenic in healthy adults who had been immunised
with three doses of CoronaVac.

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