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Novel anti-VEGF agent provides additional benefit when combined with ranibizumab for neovascular age-related macular degeneration

1. In a phase 2 randomized trial, intravitreal injection with both ranibizumab and OPT-302, a VEGF-C and -D inhibitor, led to greater improvement in visual acuity at 24 weeks than ranibizumab alone in patients with neovascular age-related macular degeneration (AMD). 2. OPT-302 was not associated with increased risk of adverse events. Evidence Rating Level: 1
Rating Level Age Related Macular Degeneration Phase 2 Phase 2 Clinical Trial 2 Minute Medicine

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