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Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis

Benjamin Speich and colleagues investigate whether rates of trial completion and publication have increased over the past decade, the extent to which non-published trials can be identified in registries, and the association between reporting quality of protocols and premature discontinuation or non-publication of trials.
United States United Kingdom Aarons Kesselheim Contract Research Organization Swiss Federal Office Of Public Health European Union Clinical Trial Registry
Source: plos.org

Evaluation of HIV treatment outcomes with reduced frequency of clinical encounters and antiretroviral treatment refills: A systematic review and meta-analysis

Noelle Le Tourneau and co-workers study HIV outcomes in studies investigating reduced frequency of antiretroviral drug provision and clinical consultations.
United Kingdom Le Tourneau Marie Louise Newell International Clinical Trials Registry Platform University Of Southampton World Health Organization
Source: plos.org

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Interventions to reengage people living with HIV who are lost to follow-up from HIV treatment programs: A systematic review and meta-analysis

Author summary Why was this study done? Sustained engagement and retention in HIV care is critical for optimal HIV treatment outcomes and reduced HIV transmission. For many people living with HIV, disengagement is inevitable during the long course of HIV treatment. It remains unclear which combination of reengagement strategies are most effective and under what conditions. What did the researchers do and find? Our systematic review identified 37 studies (6 randomized trials and 31 observat...
New York United States South Africa United Kingdom Marie Louise Newell National Institute On Drug Abuse
Source: plos.org

Expanding syphilis test uptake using rapid dual self-testing for syphilis and HIV among men who have sex with men in China: A multiarm randomized controlled trial

In a multi-arm randomized controlled trial, Cheng Wang and colleagues determine the effectiveness and cost of expanding syphilis self testing among men who have sex with men in China.
United States North Carolina Southern Medical University Dermatology Hospital Drug Administration World Health Organization Sojump Changsha Haoxing Information Technology
Source: plos.org

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