Page 9 - Randomized Controlled Trials News Today

Author summary Why was this study done? ➢ Clinicians and researchers depend on the peer-reviewed literature for accurate assessments of drug efficacy and safety, but this depends on whether the outcomes of all trials—negative, as well as positive—are reported transparently. ➢ In an earlier study, using Food and Drug Administration (FDA) review documents as a gold standard, we found that many negative trials had been misreported in the published literature as having po...

Caroline McCarthy and colleagues investigate the effect of a general practitioner-delivered, individualized medication review on polypharmacy and potentially inappropriate prescribing in community dwelling older patients with multimorbidity in Irish primary care.

In a cluster randomized trial, Jane S Hocking and colleagues investigate the impact of removing financial incentives and/or audit and feedback on chlamydia testing in general practice in Australia.

Researchers present available evidence on the activity of Echinacea purpure against coronavirus infections.

Singapore: A meta-analysis of 15 randomized controlled trials of SGLT2 inhibitors for diabetes and non-diabetes patients, showed no significant difference in amputation risk for the various SGLT2...

“Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” Those words, uttered by two-time Nobel Prize-winning chemist and physicist Marie Curie, are as relevant today as they were in her era (1867–1934). With most of the planet under some form of medical martial law, we would do well to follow her advice: understand more and fear less about the pandemic. The way to do that is to establish the verifiable, scientific facts...

A leader from the advanced data and artificial intelligence specialist suggests ways to advance data collection through new tools, techniques, and thinking.

Marie Stoner and co-workers assess the evidence on potential benefits of cash transfer interventions for HIV prevention.

A large review and meta-analysis of 167 studies across 60 years dissects placebo-controlled randomized controlled trials of antipsychotic drugs.

Florian Naudet and co-authors discuss strengthening requirements for sharing clinical trial data.