Replication Competent News Today

In a report published on March 21, 2024 in EMBO Molecular Medicine (A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion) investigators at Seattle Children's Research Institute and Sanaria Inc. describe the development of a whole malaria parasite vaccine strain that infects the liver, develops to the late liver stage, and then gets completely stuck and cannot burst out of the liver to cause symptomatic blood infection.

Rapid, Sensitive, and Validated Detection of Viral Replication Genes Using Droplet Digital™ PCR During Cell and Gene Therapy Production.

If you give them the opportunity to spread, you are giving them ample room to mutate. now, not every mutation is going to wind up being functionally important. but if you let it mutate enough, sooner or later you may get a constellation of mutations that would lead to a variant that might evade the vaccine much more than the current delta is evading. it might be as replication competent, but even more serious, which gets back again, fareed, to the recurring theme. you can prevent that from happe...