Twisted DNA Increases CRISPR Off-target Effects
Understanding how Cas9 binds off-target sequences can help researchers refine CRISPR-mediated genome editing.
Source: the-scientist.com
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Epigenetic Therapy Reverses Endocrine-Resistant Breast Cancer Growth
Garvan researchers have revealed a reason why endocrine resistance develops in breast cancers and how to potentially treat it in patients.
Clare Stirzaker Joanna Achinger Kawecka Susan Clark Cancer Group At Garvan Head Of The Epigenetic Biomarker Group Technology Network
Source: technologynetworks.com
Protein Shapes Indicate Parkinson's Disease | Technology Networks
Researchers have found that a set of proteins have different shapes in the spinal fluid of healthy individuals and Parkinson’s patients. These could be used in the future as a new type of biomarker for this disease. 
Paola Picotti Professor Paola Picotti Nature Structural Molecular Biology Natalie De Souza Struct Mol
Source: technologynetworks.com
Three-Step Mechanism Provides Defense Against Hepatitis B
Researchers have deciphered the precise mechanism that allows our body to defend itself against hepatitis B.
United States Michel Strubin Geneva Centre For Inflammation Research Gilead Sciences Department Of Microbiology University Of Geneva
Source: technologynetworks.com
Frontiers | Commentary: Lethal Pneumonia Cases in Mojiang Miners (2012) and the Mineshaft Could Provide Important Clues to the Origin of SARS-CoV-2
Introduction It has been more than 1 year since the Covid-19 pandemic began in 2020 (1). The evolutionary origins of the SARS-CoV-2 virus can be partially traced to a lineage in bats; the closest known relative to SARS-CoV-2 (RaTG13) was found in a bat fecal sample taken from an abandoned mineshaft in Mojiang, China (2, 3). SARS-CoV-2 is proposed to have evolved via an intermediate host between bats and humans, or through natural selection in humans through direct contact with bats (2). Followi...
Source: frontiersin.org