Weekly Rewinds News Today

Cardiovascular risk associated with social determinants of health at individual and area levels 1. In this cohort study, individual and area level social determinants of health (SDOH) were associated with an increased risk in atherosclerotic cardiovascular disease (ASCVD) events. Evidence Rating Level: 1 (Excellent) Social determinants of health (SDOH) are several conditions that affect people’s

Efficacy and safety of sitagliptin with basal-plus insulin regimen versus insulin alone in non-critically ill hospitalized patients with type 2 diabetes: SITA-PLUS hospital trial 2. Patients randomized to receive and addition of sitagliptin to insulin therapy provided non-critically ill hospitalized patients with type 2 diabetes (T2DM) better glycemic control and higher mean daily glucose level

Sarcopenia and Sarcopenic Obesity and Mortality Among Older People 1. In this secondary analysis of the Rotterdam study, older adults with sarcopenia and sarcopenic obesity (SO) were at significantly higher risk for all-cause mortality than their non-SO counterparts. Evidence Rating Level: 2 (Good) Sarcopenia, or low skeletal muscle mass and strength, is a phenotype of

Concomitant Use of Selective Serotonin Reuptake Inhibitors With Oral Anticoagulants and Risk of Major Bleeding 1. This case-control study found that in patients with atrial fibrillation concomitant Serotonin Reuptake Inhibitor (SSRI) and Oral Anticoagulants (OAC) was associated with an increased risk of major bleeding compared with OAC use alone. 2. This increased risk was highest

Early vs Late Fixation of Extremity Fractures Among Adults With Traumatic Brain Injury 1. In a cohort of patients with traumatic brain injury, early fixation of extremity fractures within 24 hours of injury was not associated with greater rates of unfavourable functional outcomes at 6 months. Evidence Rating: 2 (Good) While extremity fractures are commonly

Traumatic Brain Injury and Subsequent Risk of Brain Cancer in US Veterans of the Iraq and Afghanistan Wars 1. Among United States veterans of the Iraq and Afghanistan wars, the experience of a moderate, severe, or penetrating traumatic brain injury was associated with a greater risk of developing brain cancer. Evidence Rating Level: 2 (Good)

Maternal autistic traits and adverse birth outcomes 1. A cohort study found that increased maternal autistic traits were associated with a greater risk of adverse birth outcomes. 2. Women who scored in the clinical range for AQ-J10 were more likely to be young and have higher levels of psychological distress. Evidence Rating Level: 1 (Excellent)

Exposure to residential green and blue space and the natural environment is associated with a lower incidence of psychiatric disorders in middle-aged and older adults: findings from the UK Biobank Evidence Rating Level: 2 (Good) 1. In this longitudinal study, exposure to green, blue, and natural spaces was beneficial for reducing the risk of developing

Short-Stay Units vs Routine Admission From the Emergency Department in Patients With Acute Heart Failure: The SSU-AHF Randomized Clinical Trial 1. This multicentre, randomized, comparative effectiveness study found that the short-stay unit (SSU) was often as effective as hospitalization in patients with new onset of acute heart failure (AHF) and otherwise low-risk profiles. 2. There

Effect of probiotic supplementation on lipoprotein-associated phospholipase A2 in type 2 diabetic patients: a randomized double-blind clinical controlled trial 1. Patients with type 2 diabetes randomized to using probiotic supplements were found to have significantly reduced lipoprotein-associated phospholipase A2 levels at 12-weeks follow-up. 2. Probiotic supplementation was also associated with improved glycemic control at follow-up.