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IMAGE: Wyss Institute researchers have developed eRapid technology as an affinity-based, low-cost electrochemical diagnostic sensor platform for the multiplexed detection of clinically relevant sepsis biomarkers in whole blood. view more
Credit: Wyss Institute at Harvard University
(BOSTON) Many life-threatening medical conditions, such as sepsis, which is triggered by blood-borne pathogens, cannot be detected accurately and quickly enough to initiate the right course of treatment. In patients that have been infected by an unknown pathogen and progress to overt sepsis, every additional hour that an effective antibiotic cannot be administered significantly increases the mortality rate, so time is of utmost essence.
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IMAGE: In their machine learning-based capsid diversification strategy, the team focused on a 28 amino acid peptide within a segment of the AAV2 VP3 capsid protein that exposes the AAV capsid. view more
Credit: Wyss Institute at Harvard University (original by Drew Bryant)
(Boston) Adeno-associated viruses (AAVs) have become promising vehicles for delivering gene therapies to defective tissues in the human body because they are non-pathogenic and can transfer therapeutic DNA into target cells. However, while the first gene therapy products approved by the Federal Drug Administration (FDA) use AAV vectors and others are likely to follow, AAV vectors still have not reached their full potential to meet gene therapeutic challenges.
All-female research team wins funding from Innovate UK to commercialise new chemical reactor
The Spinning Mesh Disc Reactor works like a vinyl record player, allowing fast, low-cost and sustainable creation of chemicals and compounds
Reactor could make chemical producers more flexible and responsive to emerging health issues such as pandemics
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone.
The scientists analyzed how magnetic nanoparticles can be manipulated in in vitro conditions to achieve a selective antitumor effect. The method is based on the combined action of nanoparticles and permanent magnetic fields on human tumor cells.