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ASCO GU 2020: Next-Generation Sequencing (NGS) of Tumor Tissue from >4000 Men with mCRPC: The PROfound Phase III Study Experience
San Francisco, California (UroToday.com) Metastatic castration-resistant prostate cancer (mCRPC) is a molecularly heterogeneous disease, with between 20 and 25% of patients with mCRPC harboring deleterious alterations in DNA damage repair genes, including those with direct or indirect roles in homologous recombination repair (HRR). These gene alterations, of which
BRCA1,
BRCA2, and
ATM are the most well-characterized, can confer sensitivity to PARP inhibition. The PROfound study showed that olaparib provides a statistically significant improvement in radiographic progression-free survival versus physician’s choice of enzalutamide or abiraterone in mCRPC patients with alterations in genes with a direct or indirect role in the HRR pathway.
NEW YORK – Billy Cole said the restaurant has lost tens of thousands of dollars since the start of the pandemic, if not $100,000.
Workers have been furloughed and salaries cut at Little Dokebi, a Korean restaurant in Brooklyn s Greenpoint neighborhood. Despite the losses, it s been one of the lucky ones because it s on a corner with plenty of outdoor dining space, said Cole, the general manager.
After this week s snowstorm signaled the start of cold weather and the governor renewed a ban on indoor dining, Cole knows it s going to be almost exclusively takeout and delivery orders that drive business for the next several months.
Right before our eyes, the most egregious aspect of COVID-19 has had its ugly head raised since the first news of the impending pandemic. Much of our attention during this pandemic has been focused on its deadly nature; economic impact; disruption in education; and the political battle over wearing face masks. But none of us have paid attention the blatant disregard for medical ethics.
Let me frame this column by saying a little bit about medical ethics. Put simply, this is a branch of medicine that examines (and upholds) the concepts/principles of autonomy, non-maleficence, beneficence, and justice. Respect for autonomy – the patient has the right to refuse or choose their treatment. Beneficence – a medical provider should always act in the best interest of the patient. Non-maleficence – to not be the cause of harm. In other words, whatever is done to a patient, it should provide the potential for more good than harm. Justice – concerns the distribution of scarce health res
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