The school was founded in 1949 by the Asanteman traditional authority, the British Colonial Government, the Methodist Church Ghana, and the Presbyterian Church of Ghana. The School is named after the King of Ashanti, (Asantehene) Osei Tutu Agyeman Prempeh II, who donated the land on which the school was built and was modeled on Eton College in England. The school topped matriculation at the Kwame Nkrumah University of Science and Technology in 2004 with 441 students admitted and in 2012, with 296 students from the college admitted, and is considered to be one of the best secondary schools in Ghana. The school won the National robotics championships a record three times between 2013 and 2016.