A multipronged approach to mitigate childhood adversity and build resiliency A hot topic symposia session during the Pediatric Academic Societies (PAS) 2021 Virtual Meeting will discuss a multipronged approach to addressing childhood adversity and promoting resilience - at the clinical, systems, community and educational levels. The effect of adverse childhood experiences (ACEs) on health outcomes across the lifespan is well recognized among pediatric practitioners. Increasing the ability of healthcare providers to recognize and respond to ACEs can buffer the long-term negative physical and mental health impacts of adversity and increase patient-centered care. In the era of COVID-19, employing a trauma-informed approach to care is of even graver importance because the reverberations of the overactivity of the biological stress response during this time will affect populations both in the near and distant future. Understanding the biological impact of stress and childhood adversity and recognizing ways in which to mitigate this impact and build resiliency is key. Our panel will serve this function."