Date Time AstraZeneca ChAdOx1–19 The Therapeutic Goods Administration (TGA) is closely reviewing reports of anaphylaxis after four cases were reported following the AstraZeneca ChAdOx1-S vaccine in the past 2 days in Queensland. Anaphylaxis is a form of allergic reaction. It is a very rare side effect that may occur with any vaccine. The Australian Technical Advisory Group on Immunisation (ATAGI) advice emphasises that people without a previous history of specific or severe allergy should be observed post vaccination for the recommended 15 minute period. Only those with specific allergies or a previous history of anaphylaxis may require vaccination in a facility with medical staff in attendance, and to be observed for 30 minutes following administration of a COVID-19 vaccine dose. This advice can be found at: Clinical Guidance on use of COVID-19 vaccine in Australia in 2021 (v2.0) (pdf,515kb).