At Last! Establishment Pushback Against Puberty Blocking Commentary In the name of “gender affirmation,” pre-pubescent children and adolescents diagnosed with gender dysphoria are administered substances that impede natural puberty and prevent the normal development of secondary sex characteristics. These hormones and substances were approved for treating pathologies in adolescence, not for preventing normal maturation. Such “off label” uses of these substances is rank experimentation conducted on children. It is one thing when adults make these life-altering decisions. But impeding natural growth in children should be quite another. Alas, in recent years, the medical establishment has been swept along by the transgender moral panic.