Best mattress for back pain in 2021 Waking up with back pain? These mattresses combine comfort and support for a restful night and a pain-free morning. Listen - 02:23 Do you wake up feeling like you've been hit by a truck? Assuming you're going to bed at a reasonable hour and catching enough Zs, chances are that the problem is your mattress. One of the biggest signs that there's something off with your mattress is persistent back pain. Now, there are lots of reasons one might have back pain, from hard work outs to sitting at a desk all day, but if your back even feels a little off, sleeping on the wrong mattress will almost certainly make you feel even worse.