Introduction In September 2019, the U.S. House of Representatives passed the “Secure and Fair Enforcement (SAFE) Banking Act of 2019”, 1 the first stand-alone cannabis legislation to be approved by the House of Representatives. Earlier this month, revised versions of the bill were introduced in the House and Senate “to reform federal cannabis laws and reduce the public safety risk in communities across the country.” 2 Current Status Representatives Ed Perlmutter (D-CO-7), Nydia Velázquez (D-NY-7), Steve Stivers (R-OH-15), and Warren Davidson (R-OH-8) introduced the “SAFE Banking Act of 2021” 3 on 18 March. To-date, they have recruited an additional 120 co-sponsors, including 16 additional Republicans. In the 116th Congress, the bill had 202 additional co-sponsors, including 25 additional Republicans, and was approved by a vote of 321-103 (including 102 Republicans).