CHOP researchers engineer stable, universal MHC-I molecules

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens.

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University Of Pennsylvania , Pennsylvania , United States , Fox Chase Cancer Center , Philadelphia , Michaelc Young , George Burslem , Lily Ramsey , Nikolaosg Sgourakis , Yi Sun , Claireh Woodward , Sgourakis Lab , Proceedings Of The National Academy Sciences , National Academy , Senior Author , Associate Professor , Genomic Medicine , Antigen , Dancer , Fell , Children , Hospital , Immune Response , Immune System , Immunotherapy , Olecule , Eptides , Research , Vaccine ,