email article Cannabis has become an integral part of pain medicine despite a lack of clear evidence to support its use, an expert said at the 2021 virtual American Academy of Pain Medicine meeting. "Some patients with chronic pain clearly benefit from medical cannabis," said Elon Eisenberg, MD, of Rambam Health Care and the Technion Israel Institute of Technology in Haifa, in a special session about cannabis. The endo-cannabinoid system is involved in pain control at the peripheral, spinal, and supra-spinal levels, Eisenberg observed. "Cannabinoid receptor activity inhibits the ascending nociceptive transmission, activates the inhibitory descending pathways, and modifies the emotional component of pain which is important by itself."