COVID-related inflammatory syndrome looks different in adult

COVID-related inflammatory syndrome looks different in adults


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The postinfectious COVID-19–related multisystem inflammatory syndrome (MIS) first characterized in children has a different presentation in adults that may lead to underrecognition, according to a small, single-center study today in
JAMA Network Open.
Conducted by researchers at Vanderbilt University Medical Center, the retrospective study involved 15 patients 21 years and older who met the working definition for MIS in adults (MIS-A) from Mar 1 to Sep 30, 2020, and were hospitalized 14 to 84 days after testing positive for COVID-19 or 15 days before or after SARS-CoV-2 antibody test results identified them as at risk for the syndrome.
Median of four organs affected
The 15 MIS-A patients were compared with 683 hospitalized COVID-19 patients without MIS-A. MIS-A patients were younger than those with acute COVID-19 (median age, 45.1 vs 56.5 years) and more likely to have coronavirus antibodies on serologic testing (9 [60%] vs 0), suggesting a previous infection. Other demographic characteristics and underlying illnesses were similar between the two groups.

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