DarwinHealth Scientists Publish Foundational Research Identifying Regulatory Mechanisms Controlling Cancer Cell States and Drug Response News provided by Share this article Share this article NEW YORK, Jan. 11, 2021 /PRNewswire/ -- DarwinHealth, Inc., a New York-based biotechnology and cancer drug discovery company announces the January 11, 2021 online publication in Cell of a landmark paper, "A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity," 1,2 in which scientists from Columbia University and DarwinHealth apply the VIPER (Virtual Inference of Protein activity by Enriched Regulon) analysis algorithm to identify recurrent regulatory networks—"tumor checkpoints"—operative across the pancancer subtype continuum. This research paper, with lead author Dr. Evan Paull, from the Department of Systems Biology at Columbia University, in conjunction with DarwinHealth Co-Founder, Professor Andrea Califano and Chief Scientific Officer, Dr. Mariano Alvarez and other investigators, presents results and analyses, using a novel Multi-Omics Master-Regulator Analysis framework (MOMA), that validates the foundational paradigm informing DarwinHealth technologies.