let notgood night, frank. way. good night. desperate for nighttime heartburn relief? for many, nexium helps relieve heartburn symptoms caused by acid reflux disease. talk to your doctor about your risk for osteoporosis-related bone fractures if you take multiple daily doses of nexium for a long time. possible side effects include headache, diarrhea, and abdominal pain. other serious stomach conditions may still exist. talk to your doctor about nexium. if you can't afford your medication, astrazeneca may be able to help.