Palm Springs Desert Sun California has changed its COVID-19 vaccine rules yet again, with officials saying they will now target the state's most at-risk ZIP codes for doses, including several dozen in San Bernardino County, in an effort to get the state's economy open more quickly. About 40% of doses will be spread out among more than 400 ZIP codes with about 8 million people eligible for shots, said Dr. Mark Ghaly, the state's health and human services secretary. Several of those neighborhoods are located in the high desert and Inland Empire. Once 2 million vaccine doses are given out in those neighborhoods, the state will make it easier for counties to move through the tiers that dictate business reopenings.