Electron cryo-microscopy sheds light on how bioenergy makers

Electron cryo-microscopy sheds light on how bioenergy makers are made in our body


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IMAGE: Mitoribosomes are tethered to the mitochondrial inner membrane to facilitate insertion of synthesized proteins (yellow) encoded by the mitochondrial genome. A gating mechanism of the exit tunnel (cyan) enables protein...
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Credit: Dan W. Nowakowski and Alexey Amunts
Mitochondria are organelles that act as the powerhouses in our body. They use oxygen which we inhale and food we eat to produce energy that supports our life. This molecular activity is performed by bioenergetic nano-factories incorporated in specialized mitochondrial membranes. The nano-factories consist of proteins cooperatively transporting ions and electrons to generate chemical energy. Those have to be constantly maintained, replaced and duplicated during cell division. To address this, mitochondria have their own bioenergy protein-making machine called the mitoribosome. Given its key role, a deregulation of the mitoribosome can lead to medical disorders such as deafness and diseases including cancer development. The first fundamental understanding of how mitoribosomes look was achieved in 2014.

Related Keywords

Alexey Amunts , , Resolution Revolution , Biology , Biochemistry , Biomechanics Biophysics , Cell Biology , Revolution , Molecular Biology , தீர்மானம் புரட்சி , உயிரியல் , உயிர் வேதியியல் , பயோமெக்கானிக்ஸ் உயிர் இயற்பியல் , செல் உயிரியல் , பரிணாமம் , மூலக்கூறு உயிரியல் ,

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