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Electron cryo-microscopy sheds light on how bioenergy makers are made in our body

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IMAGE: Mitoribosomes are tethered to the mitochondrial inner membrane to facilitate insertion of synthesized proteins (yellow) encoded by the mitochondrial genome. A gating mechanism of the exit tunnel (cyan) enables protein.
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Credit: Dan W. Nowakowski and Alexey Amunts
Mitochondria are organelles that act as the powerhouses in our body. They use oxygen which we inhale and food we eat to produce energy that supports our life. This molecular activity is performed by bioenergetic nano-factories incorporated in specialized mitochondrial membranes. The nano-factories consist of proteins cooperatively transporting ions and electrons to generate chemical energy. Those have to be constantly maintained, replaced and duplicated during cell division. To address this, mitochondria have their own bioenergy protein-making machine called the mitoribosome. Given its key role, a deregulation of the mitoribosome can lead to medical disorders such as deaf ....

Alexey Amunts , Resolution Revolution , Biomechanics Biophysics , Cell Biology , Molecular Biology , தீர்மானம் புரட்சி , உயிர் வேதியியல் , பயோமெக்கானிக்ஸ் உயிர் இயற்பியல் , செல் உயிரியல் , மூலக்கூறு உயிரியல் ,

New Data sheds light on genesis of our body's powerhouses

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IMAGE: The mitoribosome is attached to its membrane adaptor as it synthesises a bioenergetic protein (glow yellow).
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Credit: Dan W. Nowakowski and Alexey Amunts
Scientists uncover for the first time how the body s energy makers are made using Cryo-Electron Microscopy (cryo-EM) at eBIC within Diamond which is based in Oxfordshire.
A new paper published in
Science today (19 February 2021) by an international team of researchers reports an insight into the molecular mechanism of membrane-tethered protein synthesis in mitochondria. This is a fundamental new understanding of how the human mitoribosome functions and could explain how it is affected by mutations and deregulation that lead to disorders such as deafness and diseases including cancer development. ....

United States , United Kingdom , Eteläuomen Läi , Newcastle Upon Tyne , Karolinska Institutet , Uwe Richter , Alexey Amunts , Austin Choi , Brendanj Battersby , Priyanka Maiti , Yuriy Chaban , Yuzuru Itoh , Juni Andr , Rosalind Franklin Institute , National Institute Of Diabetes , Department Of Neurology , Science For Life Laboratory , Stockholm University , Department Of Biochemistry , Technology Facilities Council , Newcastle University , Department Of Medical Biochemistry , Research Council , Electron Physical Science Imaging Centre , University Of Helsinki , National Institutes Of Health ,

January issue of <i>SLAS Discovery</i>

January issue of
SLAS (Society for Laboratory Automation and Screening)
Oak Brook, IL - The January edition of
SLAS Discovery features the cover article, Cryo-EM: The Resolution Revolution and Drug Discovery by Taiana Maia de Oliveira, Ph.D., Lotte van Beek, Ph.D., Fiona Shilliday, Ph.D., Judit E. Debreczeni, Ph.D., and Chris Phillips, Ph.D., from AstraZeneca.
Cryo-EM, a fast-growing technique in the pharmaceutical industry, enables structure determination of sought-after targets such as large multiprotein complexes and membrane proteins that eluded other structural biology methods. The intricate interactions between compounds and proteins are crucial in accelerating the drug discovery process. The cover article reviews how the structural understanding gained through Cryo-EM is influencing drug discovery projects focused on TRP channels, GPCRs, ribosomes and other high value targets. ....

United States , Fiona Shilliday , Judite Debreczeni , Robertm Campbell , Lotte Van Beek , Chris Phillips , Edward Kai Hua Chow , Microscale Thermophoresis , Innovative Tools For Biomedical Research , Society For Laboratory Automation , Life Sciences Innovation , Fluorescence Resonance Energy Transfer , Development Of High , Articles Of Original Research , National University Of Singapore , Oak Brook , Resolution Revolution , Taiana Maia De Oliveira , Original Research , Plate Cryopreservation , Cell Models , Innovative Tools , Biomedical Research , Preclinical Drug Discovery , Based Affinity Selection Mass Spectrometry , Automated Screening ,