What is already known about this topic? Injuries are a leading cause of death among U.S. adults aged ≥65 years; nonfatal injuries among this age group are more common and result in long-term health consequences, including brain injuries or the loss of independence. What is added by this report? In 2018, an estimated 2.4 million emergency department visits and >700,000 hospitalizations occurred among older adults as a result of injuries from falls, motor vehicle crashes, opioid overdoses, and self-harm. Unintentional falls accounted for >90% of these visits. What are the implications for public health practice? Injuries are not an inevitable part of aging. Educational campaigns that use positive messages can encourage older adults to speak with their health care provider about preventing injuries. Health care providers can help prevent injuries by referring to physical therapy and deprescribing certain medications.