Estimated impact of tafenoquine for Plasmodium vivax control

Estimated impact of tafenoquine for Plasmodium vivax control and elimination in Brazil: A modelling study


Despite recent intensification of control measures,
Plasmodium vivax poses a major challenge for malaria elimination efforts. Liver-stage hypnozoite parasites that cause relapsing infections can be cleared with primaquine; however, poor treatment adherence undermines drug effectiveness. Tafenoquine, a new single-dose treatment, offers an alternative option for preventing relapses and reducing transmission. In 2018, over 237,000 cases of malaria were reported to the Brazilian health system, of which 91.5% were due to
P.
Methods and findings
We evaluated the impact of introducing tafenoquine into case management practices on population-level transmission dynamics using a mathematical model of
P.
P.
vivax endemic settings in Brazil in 2018, informed by nationwide malaria case reporting data. Parameters for treatment pathways with chloroquine, primaquine, and tafenoquine with glucose-6-phosphate dehydrogenase deficiency (G6PDd) testing were informed by clinical trial data and the literature. We assumed 71.3% efficacy for primaquine and tafenoquine, a 66.7% adherence rate to the 7-day primaquine regimen, a mean 5.5% G6PDd prevalence, and 8.1% low metaboliser prevalence. The introduction of tafenoquine is predicted to improve effective hypnozoite clearance among

Related Keywords

United States , Manaus , Amazonas , Brazil , Brazilian , America , Grewal Daumerie , Alexandre Menezes , Melanie Larson , Gonzalo Domingo , Elodie Jambert , Brazilian Institute Of Geography , Brazilian Institute , South America , Penny Grewal Daumerie , Primaquine , Plasmodium , Malaria , Chloroquine , Epidemiology , Parasitic Diseases , Pediatrics , ஒன்றுபட்டது மாநிலங்களில் , ம்யாநாயஸ் , அமசோனாஸ் , பிரேசில் , பிரேசிலியன் , அமெரிக்கா , அலெக்ஸாண்ட்ரே மெனிசஸ் , மெலனி லார்சன் , கோன்சலோ டொமிஂகொ , பிரேசிலியன் நிறுவனம் ஆஃப் நிலவியல் , பிரேசிலியன் நிறுவனம் , தெற்கு அமெரிக்கா , மலேரியா , தொற்றுநோய் , ஒட்டுண்ணி நோய்கள் , குழந்தை மருத்துவம் ,

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