email article Inactivity among patients with systemic lupus erythematosus (SLE) was associated with a more than threefold increased risk for development of depression, researchers reported. Among patients who described themselves as inactive at baseline, incident depression was diagnosed during the subsequent 2 years in 38% of SLE patients, compared with 14% of those who were active, according to Sarah L. Patterson, MD, and colleagues from the University of California San Francisco. In a multivariate analysis that adjusted for sex, race, comorbidities, and disease activity and damage, the hazard ratio for incident depression among inactive SLE patients was 3.88 (95% CI 1.67-9.03), the researchers reported online in