How to Administer Epinephrine Shots Your healthcare provider can show you how to administer epinephrine shots, and you should always read the instructions after filling your prescription. Training devices (without a needle or medication) can also hone your skills in giving an EpiPen dose. Practicing and discussing the shot with your child before an emergency can help them become a willing participant. Children must hold still during the injection. If they can't, have another adult hold them—or you can lay down across their chest to keep them stationary. Use one hand to hold your kid's leg and the other hand to give the injection.