The COVID Variants COVID-19 variant cases have already been found in all provinces, causing outbreaks in long-term care homes and derailing election plans in Newfoundland and Labrador. Genetic mutations often occur in viruses, and SARS-CoV-2, the coronavirus that causes COVID-19, is no exception. When the changes are significant, the new mutated form is called a variant. A variant would be of concern if it impacts the spread or severity of the disease, as well as if it has a different response to tests or vaccines and treatments, according to Health Canada. So far all variants of concern that have spread globally have also been found in Canada. Here’s a look at these variants.