Increased physical activity attenuated APOE ε4-related vulnerability to early cognitive decline in Parkinson’s disease (PD) patients, a retrospective cohort study found. “This study provides Class II evidence that increased physical activity was associated with decreased APOE ε4-related early cognitive decline in PD patients,” wrote Jin-Sun Jun, MD, of Hallym University in Seoul, Korea, and co-authors in “This protective effect did not appear to be mediated by striatal dopaminergic function,” they added. Jun and colleagues analyzed data from the Parkinson’s Progression Markers Initiative. All 173 patients (baseline mean age: 63 years) were recently diagnosed with idiopathic PD and had abnormal dopamine transporter (DAT) imaging while untreated. In all, 27% were