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For α-Synuclein Immunotherapy, Is Going Later the Key?


04 Apr 2021
α-Synuclein immunotherapy is in its infancy, with few trials posting results yet. The first two completed Phase 2s, of Biogen’s cinpanemab and Prothena and Roche’s prasinezumab, were both negative. However, while the cinpanemab study was fully negative, prasinezumab posted positive results on some secondary motor measures. At the 15th International Conference on Alzheimer’s and Parkinson’s Diseases, held virtually March 9–14,
Gennaro Pagano of Roche gave researchers a first look at prespecified subgroup analyses from this study, called PASADENA. It turned out that subgroups of participants whose disease progressed fastest benefited more from prasinezumab, with more slowing of motor decline. Pagano believes this is because the signal-to-noise ratio in these subgroups was greater, allowing the small effect of prasinezumab to be discerned more readily in this slow disease. ....

City Of , United Kingdom , Lundbeck Lu , Tim Bartels , Gennaro Pagano , Madolyn Bowman Rogers , Kirsten Taylor , Werner Poewe , Tiago Outeiro , Innsbruck Medical University , Parkinson Progression Markers Initiative , University Medical Center , International Conference On Alzheimer , University Medical Center Goettingen , International Conference , Progression Markers , Research Institute , University College , Madolyn Bowman , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , நேரம் பார்ட்டல்கள் , ஜெம்நாரோ ப்யாகநொ , கர்ஸ்டந் டெய்லர் , தியகோ ஔஊடேறோ , இந்ந்‌ஸ்ப்ரக் மருத்துவ பல்கலைக்கழகம் ,

Increased Physical Activity Attenuated Cognitive Decline in Parkinson's Patients with APOE Ε4


Increased physical activity attenuated
APOE ε4-related vulnerability to early cognitive decline in Parkinson’s disease (PD) patients, a retrospective cohort study found.
“This study provides Class II evidence that increased physical activity was associated with decreased
APOE ε4-related early cognitive decline in PD patients,” wrote Jin-Sun Jun, MD, of Hallym University in Seoul, Korea, and co-authors in
“This protective effect did not appear to be mediated by striatal dopaminergic function,” they added.
Jun and colleagues analyzed data from the Parkinson’s Progression Markers Initiative. All 173 patients (baseline mean age: 63 years) were recently diagnosed with idiopathic PD and had abnormal dopamine transporter (DAT) imaging while untreated. In all, 27% were ....

Soult Ukpyolsi , South Korea , United States , Jacob Raber , Paul Smyth , Jin Sun Jun , National Research Foundation , Oregon Health Science University In Portland , Parkinson Progression Markers Initiative , Hallym University , Ministry Of Science , Progression Markers , Physical Activity Scale , Montreal Cognitive Assessment , Oregon Health , Science University , Contributing Writer , தெற்கு கொரியா , ஒன்றுபட்டது மாநிலங்களில் , ஜாகோப் ரப்பர் , பால் ஸ்மித் , ஜின் சூரியன் ஜூன் , தேசிய ஆராய்ச்சி அடித்தளம் , ஓரிகந் ஆரோக்கியம் அறிவியல் பல்கலைக்கழகம் இல் போர்டிலந்ட் , பார்கின்சன் ப்ரோக்ரெஶந் குறிப்பான்கள் முயற்சி , அமைச்சகம் ஆஃப் அறிவியல் ,

Longevity Acquisition Corporation Announces 4D pharma Joining Landmark Parkinson's Progression Markers Initiative


Longevity Acquisition Corporation Announces 4D pharma Joining Landmark Parkinson s Progression Markers Initiative
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NEW YORK, Dec. 21, 2020 /PRNewswire/ Longevity Acquisition Corporation (NASDAQ: LOAC) (the Company ), a publicly-traded special purpose acquisition company, announced today that on December 18, 2020, 4D pharma plc (AIM: DDDD) ( 4D pharma ), a pharmaceutical company leading the development of Live Biotherapeutic products ( LBPs ) - a novel class of drug derived from the microbiome, and a business combination target of LOAC, has joined the Parkinson s Progression Markers Initiative ( PPMI ) as an industry partner. PPMI is a landmark study sponsored by The Michael J. Fox Foundation to better understand Parkinson s disease and accelerate the development of new treatments. ....

United States , Karen Smith , Alex Stevenson , Matthew Chen , Sohini Chowdhury , Purpose Acquisition Company , Whale Management Corporation , Exchange Commission On , Parkinson Progression Markers Initiative , Yongda International Tower No , Acquisition Corporation , Merck Co Inc , Longevity Acquisition Corporation , Advantage Proxy Inc , Securities Exchange , Michaelj Fox Foundation , Prnewswire Longevity Acquisition Corporation , Progression Markers Initiative , Partner Scientific Advisory Board , Advisory Board , Chief Scientific Officer , Progression Markers , Scientific Advisory Board , Special Purpose Acquisition Company , Exchange Commission , Irritable Bowel Syndrome ,

Investegate |4d Pharma PLC Announcements | 4d Pharma PLC: Joins MJFF-sponsored Parkinson's study consortium


4D pharma Joins Landmark Parkinson s Progression Markers Initiative
A landmark study sponsored by The Michael J. Fox Foundation to better understand Parkinson s disease and accelerate the development of new treatments
4D pharma will play an important role as PPMI considers the microbiome as an area of focus
Leeds, UK, December l8, 2020
, - 4D pharma plc (AIM: DDDD), a pharmaceutical company leading the development of Live Biotherapeutic products (LBPs) - a novel class of drug derived from the microbiome, today announces that it has joined the Parkinson s Progression Markers Initiative (PPMI) as an industry partner. PPMI is a landmark study sponsored by The Michael J. Fox Foundation to better understand Parkinson s disease and accelerate the development of new treatments. ....

United States , United Kingdom , Julie Seidel , Dominic Wilson Phil Walker , Neil Hunter Michelle Boxall , Alex Stevenson , Duncan Peyton , Sohini Chowdhury , Bryan Garnier Co , Stern Investor Relations Inc , Parkinson Progression Markers Initiative , Landmark Parkinson Progression Markers Initiative , Image Box Communications , Merck Co Inc , Longevity Acquisition Corporation , Michaelj Fox Foundation , Joins Landmark Parkinson , Progression Markers , Progression Markers Initiative , Partner Scientific Advisory Board , Advisory Board , Chief Scientific Officer , Scientific Advisory Board , Irritable Bowel Syndrome , American Depositary Shares , Longevity Shareholders ,