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For α-Synuclein Immunotherapy, Is Going Later the Key?


04 Apr 2021
α-Synuclein immunotherapy is in its infancy, with few trials posting results yet. The first two completed Phase 2s, of Biogen’s cinpanemab and Prothena and Roche’s prasinezumab, were both negative. However, while the cinpanemab study was fully negative, prasinezumab posted positive results on some secondary motor measures. At the 15th International Conference on Alzheimer’s and Parkinson’s Diseases, held virtually March 9–14,
Gennaro Pagano of Roche gave researchers a first look at prespecified subgroup analyses from this study, called PASADENA. It turned out that subgroups of participants whose disease progressed fastest benefited more from prasinezumab, with more slowing of motor decline. Pagano believes this is because the signal-to-noise ratio in these subgroups was greater, allowing the small effect of prasinezumab to be discerned more readily in this slow disease. ....

City Of , United Kingdom , Lundbeck Lu , Tim Bartels , Gennaro Pagano , Madolyn Bowman Rogers , Kirsten Taylor , Werner Poewe , Tiago Outeiro , Innsbruck Medical University , Parkinson Progression Markers Initiative , University Medical Center , International Conference On Alzheimer , University Medical Center Goettingen , International Conference , Progression Markers , Research Institute , University College , Madolyn Bowman , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , நேரம் பார்ட்டல்கள் , ஜெம்நாரோ ப்யாகநொ , கர்ஸ்டந் டெய்லர் , தியகோ ஔஊடேறோ , இந்ந்‌ஸ்ப்ரக் மருத்துவ பல்கலைக்கழகம் ,

Tech: Akár 8 hónapig is védettek lehetnek azok, akik koronavírus-betegek voltak

Tech: Akár 8 hónapig is védettek lehetnek azok, akik koronavírus-betegek voltak
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Innsbruck Medical University , University Rector , இந்ந்‌ஸ்ப்ரக் மருத்துவ பல்கலைக்கழகம் , பல்கலைக்கழகம் ரெக்டர் ,