1. In this randomized controlled trial, withholding prophylactic platelet transfusion in patients with thrombocytopenia was associated with worse outcomes following central venous catheter (CVC) placement. 2. Withholding prophylactic platelet transfusion in patients with thrombocytopenia resulted in an increased risk of CVC-related bleeding events. Evidence Rating Level: 1 (Excellent) Study Rundown: CVC placement is a frequently performed invasive