Knowing DNA Repair Toolkit to Chart Cancer Evolution by Angela Mohan on February 18, 2021 at 3:40 PM Deficiencies in DNA repair pathways increase the instability of the genes, and this causes cancer to develop. Therefore, detailed knowledge of how DNA repair pathways participate in this process is crucial for tracking tumor progression, understanding the emergence of drug resistance, and developing efficient therapeutic interventions. To this end, a group of scientists from China examined five critical DNA repair pathways and their impact on cancer evolution by reviewing the findings of the latest published research. "So, it is not surprising that particularly defective DNA repair pathways are associated with specific cancers.