E-Mail An analysis of law enforcement seizures of illegal drugs in five key regions of the United States revealed a rise in methamphetamine and marijuana (cannabis) confiscations during the COVID-19 pandemic. Seizures of the two drugs were higher at their peak in August 2020 than at any time in the year prior to the pandemic. While investigators found that trends in heroin, cocaine and fentanyl seizures were not affected by the pandemic, provisional overdose death data show that the increased drug mortality seen in 2019 rose further through the first half of 2020. The findings suggest that the pandemic and its related restrictions may have impacted the availability and demand of some, but not all, illegal drugs, and that availability may have increased in summer and fall of 2020 in the five regions included in this study.