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tell your doctor if you have an infection, liver or kidney problems, high triglycerides, or had a vaccine or plan to. sotyktu is a tyk2 inhibitor. tyk2 is part of the jak family. it s not known if sotyktu has the same risks as jak inhibitors. find what plaque psoriasis has been hiding. there s only one sotyktu, so ask for it by name. so clearly you. sotyktu. [street noise] [car door shuts] [paparazzi cameras] introducing, ned s plaque psoriasis. ned, ned, who are you wearing? he thinks his flaky red patches are all people see. otezla is the #1 prescribed pill to treat plaque psoriasis. ned? otezla can help you get clearer skin, and reduce itching and flaking. with no routine blood tests required. doctors have been prescribing otezla for over a decade. otezla is also approved to treat psoriatic arthritis. don t use otezla if you re allergic to it. serious allergic reactions can happen. otezla may cause severe diarrhea, nausea, or vomiting.