New 3M Polisher ST reduces the number of biopharma manufacturing process steps ST. PAUL, Minn., Feb. 9, 2021 /PRNewswire/ -- 3M Health Care launched 3M Polisher ST,* an advanced, single-use AEX solution designed to replace reusable AEX polishing column for biologic drug manufacturing. Polisher ST improves the biopharma manufacturing workflow by reducing the number of processing steps thereby helping to improve process economics. The new product was developed by 3M scientists who passionately create solutions to manufacture biologic drugs more efficiently. 3M Polisher ST is a synthetic, fully encapsulated, single-use membrane chromatography solution containing two complementary AEX-functional media: a quaternary ammonium ("Q") functional nonwoven and a guanidinium-functional membrane. The Q-functional nonwoven provides reduction of turbidity (when present), DNA, and endotoxin, as well as a portion of the product's AEX capacity for HCP and virus reduction. The novel guanidinium functionality in the guanidinium-functional membrane of 3M Polisher ST provides HCP and virus reduction in a salt tolerant (ST) manner.